nucleation

THEORY-1206: The mitochondrion was acquired late in eukaryogenesis, by a host whose proteome was already chimaeric, with genes from several bacterial sources acquired before it

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Properties5
StatusProposed
Tagsendosymbiosis, natural-sciences
SourceLIT-1595 — Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry
ExtendsTHEORY-1102 — On Pittis and Gabaldón's stem-length analysis of the LECA proteome, families of alphaproteobacterial origin and mitochondrial location sit closer to their prokaryotic relatives, after correction for each family's rate, than families of other bacterial origin (P = 0.044), which sit closer than archaeal families, and the authors read this as late acquisition of the mitochondrion by a host whose proteome was already chimaeric, under their stated assumption that rates before and after LECA are correlated
Bears onQUESTION-277 — When formerly autonomous partners come to depend on one another, which of mutual dependence, reproductive cohesion, the distribution of essential functions across genomes, the host's regulatory control and the alignment of selection does each route to dependence bring about, and which of them, alone or together, make the partnership a new evolutionary individual?

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Source

Pittis & Gabaldón (2016), LIT-1595, read in full in NOTE-1240. The paper’s title states it: “Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry”.

Where the evidence stands

What the paper shows, and what it does not, is THEORY-1102, Active, which this entry extends: that entry is the reading, this one the thesis. The promote_when above is THEORY-1102’s condition before the twenty-second status review promoted it, carried here unchanged, because it asks what would make the thesis true and not what the paper says.

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