Yehuda, R., Daskalakis, N. P., Bierer, L. M., Bader, H. N., Klengel, T., Holsboer, F. & Binder, E. B. (2016). Biological Psychiatry, 80(5), 372–380.
Not read. The summary is drawn from the abstract or from what the work is standardly cited for. A reading should check it first.
Why this is here
The study behind most popular claims that trauma is inherited epigenetically. For QUESTION-297.
Read in its place
The work cannot be read here, so the record holds it at second hand.
For LIT-1692 (Yehuda et al. 2016, “Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation”). Youssef et al. 2018 (NOTE-1310) give the study’s design and main result: 32 Holocaust survivors and 22 of their offspring against 8 controls and 9 control offspring, with blood FKBP5 intron 7 methylation significantly higher in survivors and significantly lower in their offspring, read as biological accommodation. They name its limits as sample size and the survivors’ starvation. The LIT’s “a site” should read “intron 7”. Missing still: who the controls were (the LIT’s “Jewish families living outside Europe” is not confirmed), the CpG sites and statistics, the sex of the exposed parent, timing of conception, genotype, cortisol results, and the offspring’s own trauma and psychopathology.