Pembrey, M. E., Bygren, L. O., Kaati, G., Edvinsson, S., Northstone, K., Sjöström, M., Golding, J. & the ALSPAC Study Team (2006). European Journal of Human Genetics, 14(2), 159–166.
Not read. The summary is drawn from the abstract or from what the work is standardly cited for. A reading should check it first.
Why this is here
The classic human epidemiological case for transgenerational effects. For QUESTION-297.
Read in its place
The work cannot be read here, so the record holds it at second hand.
For LIT-1764 (Pembrey et al. 2006, “Sex-specific, male-line transgenerational responses in humans”). Pembrey, Saffery and Bygren 2014 (NOTE-1320), by two of the original’s authors, restate its result: in Överkalix cohorts born 1895, 1905 and 1920 (n = 107, 99, 111), the paternal grandfather’s mid-childhood food supply was linked to grandsons’ mortality (rate ratios 1.67 good, 0.65 poor) and the paternal grandmother’s to granddaughters’ (2.13, 0.72). It also gives the ALSPAC result reported there: sons of fathers who began smoking before 11 had higher BMI at 9. It shows that the exposure was food supply, not famine, and that good supply was the harmful one. Missing still: the original’s methods, food-supply classification, confidence intervals and p-values, the ALSPAC sample and model, its discussion of mechanism, and the 2006 exchange with Senn on multiple testing.